Print Email Facebook Twitter Self-orienting hydrogel micro-buckets as novel cell carriers Title Self-orienting hydrogel micro-buckets as novel cell carriers Author Liu, Q. (TU Delft ChemE/Advanced Soft Matter; Beijing Normal University) Zhao, M. (TU Delft (OLD) MSE-1) Mytnyk, S. (TU Delft ChemE/Product and Process Engineering) Klemm, B. (TU Delft ChemE/Advanced Soft Matter) Zhang, K. (TU Delft ChemE/Advanced Soft Matter) Wang, Y. (TU Delft ChemE/Advanced Soft Matter) Yan, Dadong (Beijing Normal University) Mendes, E. (TU Delft ChemE/Advanced Soft Matter) van Esch, J.H. (TU Delft ChemE/Advanced Soft Matter) Date 2019 Abstract Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self-orientation of crescent-shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as micro-buckets to carry living cells. In aqueous solution, the microparticles spontaneously rotated to a preferred orientation with the cavity facing up. We developed a geometric model that explains the self-orienting behavior of crescent-shaped particles by minimizing the potential energy of this specific morphology. Finally, we selectively modified the particles’ cavities with RGD peptide and exploited their preferred orientation to load them with living cells. Cells could adhere, proliferate, and be transported and released in vitro. These micro-buckets hold a great potential for applications in smart materials, cell therapy, and biological engineering. Subject cell carriershydrogelsmicrofluidicsself-orientationsoft matter To reference this document use: http://resolver.tudelft.nl/uuid:24739610-fc02-4113-9379-5a9647a9675e DOI https://doi.org/10.1002/anie.201811374 ISSN 1433-7851 Source Angewandte Chemie (International Edition), 58 (2), 547-551 Part of collection Institutional Repository Document type journal article Rights © 2019 Q. Liu, M. Zhao, S. Mytnyk, B. Klemm, K. Zhang, Y. Wang, Dadong Yan, E. Mendes, J.H. van Esch Files PDF Liu_et_al_2018_Angewandte ... dition.pdf 2.41 MB Close viewer /islandora/object/uuid:24739610-fc02-4113-9379-5a9647a9675e/datastream/OBJ/view