Exploiting Bacteriophage Proteomes

Title

Exploiting Bacteriophage Proteomes: The Hidden Biotechnological Potential

 Author

Santos, Sílvio B. (University of Minho)
Costa, Ana Rita (University of Minho)
Carvalho, Carla (University of Minho; International Iberian Nanotechnology Laboratory)
Luzia de Nobrega, F. (TU Delft BN/Stan Brouns Lab; University of Minho; Kavli institute of nanoscience Delft) ORCID 0000-0002-8238-1083
Azeredo, Joana (University of Minho)

Date

2018

 Abstract

Bacteriophages encode many distinct proteins for the successful infection of a bacterial host. Each protein plays a specific role in the phage replication cycle, from host recognition, through takeover of the host machinery, and up to cell lysis for progeny release. As the roles of these proteins are being revealed, more biotechnological applications can be anticipated. Phage-encoded proteins are now being explored for the control, detection, and typing of bacteria; as vehicles for drug delivery; and for vaccine development. In this review, we discuss how engineering approaches can be used to improve the natural properties of these proteins and set forth the most innovative applications that demonstrate the unlimited biotechnological potential held by phage-encoded proteins.


 Subject

anti-CRISPR
bacteria control and detection
bacteriolytic activity
genetic engineering
host specificity
Phage-encoded proteins

 To reference this document use:

http://resolver.tudelft.nl/uuid:69e5b965-a6e8-4e7c-8579-00026bc80683

 DOI

https://doi.org/10.1016/j.tibtech.2018.04.006

 Embargo date

2019-08-15

 ISSN

0167-7799

 Source

Trends in Biotechnology

 Bibliographical note

Accepted Author Manuscript

 Part of collection

Institutional Repository

 Document type

journal article

 Rights

© 2018 Sílvio B. Santos, Ana Rita Costa, Carla Carvalho, F. Luzia de Nobrega, Joana Azeredo
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