Title
Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
Author
Leeuwis, Anna E. (Amsterdam UMC)
Hooghiemstra, Astrid M. (Amsterdam UMC)
Amier, Raquel (Amsterdam UMC)
Ferro, Doeschka A. (University Medical Center Utrecht)
Franken, Leonie (Amsterdam UMC)
Nijveldt, Robin (Amsterdam UMC)
Kuijer, Joost P A (Amsterdam UMC)
Bronzwaer, Anne Sophie G T (Amsterdam UMC)
van Lieshout, Johannes J. (University of Nottingham; Amsterdam UMC)
Rietberg, Marc B. (Amsterdam UMC)
Veerbeek, Janne M. (Amsterdam UMC)
Huijsmans, Rosalie J. (Amsterdam UMC)
Backx, Frank J G (University Medical Center Utrecht)
Teunissen, Charlotte E. (Amsterdam UMC)
Bron, Esther E. (Erasmus MC)
Barkhof, Frederik (Amsterdam UMC; University College London (UCL))
Prins, Niels D. (Amsterdam UMC)
Shahzad, Rahil (Leiden University Medical Center)
Niessen, W.J. (TU Delft ImPhys/Quantitative Imaging; Erasmus MC) 
de Roos, Albert (Leiden University Medical Center)
van Osch, Matthias J P (Leiden University Medical Center)
van Rossum, Albert C. (Amsterdam UMC)
Biessels, Geert J. (University Medical Center Utrecht)
van der Flier, Wiesje M. (Amsterdam UMC)
Date
2017
Abstract
There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.
Subject
Arterial spin labeling
Cerebral blood flow
Cognition
Exercise
Randomized clinical trial
Vascular cognitive impairment
To reference this document use:
http://resolver.tudelft.nl/uuid:6d35e0bd-eefa-4335-be0a-1356441c929b
DOI
https://doi.org/10.1016/j.trci.2017.02.002
Source
Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3 (2), 157-165
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2017 Anna E. Leeuwis, Astrid M. Hooghiemstra, Raquel Amier, Doeschka A. Ferro, Leonie Franken, Robin Nijveldt, Joost P A Kuijer, Anne Sophie G T Bronzwaer, Johannes J. van Lieshout, Marc B. Rietberg, Janne M. Veerbeek, Rosalie J. Huijsmans, Frank J G Backx, Charlotte E. Teunissen, Esther E. Bron, Frederik Barkhof, Niels D. Prins, Rahil Shahzad, W.J. Niessen, Albert de Roos, Matthias J P van Osch, Albert C. van Rossum, Geert J. Biessels, Wiesje M. van der Flier