Sparsity maximization approach to multiple daily injections therapy for type 1 diabetic patients

Sparsity maximization approach to multiple daily injections therapy for type 1 diabetic patients

van Wilsum, Max (TU Delft Mechanical, Maritime and Materials Engineering)

Mazo, M. (mentor)

Delft University of Technology

Mechanical Engineering | Systems and Control

2021-07-14

Based on sparsity maximization we propose a controller for Multiple Daily Injections (MDI)therapy for Type 1 Diabetes melitus (T1DM) individuals. Based on convex relaxations onthe sparsity maximization problems and by implementing personalised linear models of pa-tient we formulate a model predictive controller to determine insulin boluses. By relaxingthe constraints of the unsafe regions after meal consumption for pre-defined time interval weobtain sufficient performance with a long enough horizon. To improve the controllers perfor-mance a case-based reasoning framework is implemented to tune the controller constraintsfor increasing time spent in euglycemia.

Optimization
Control
Sparsity maximization
MDI Therapy

http://resolver.tudelft.nl/uuid:6e9f01f1-4389-4e57-a933-77983de27195

Student theses

master thesis

© 2021 Max van Wilsum