Print Email Facebook Twitter A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis: From research and development to commercialisation Title A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis: From research and development to commercialisation: from research and development to commercialization Author Meulah, Brice (Leiden University Medical Center; Centre de Recherches Medicales des Lambaréné, Lambarene) Bengtson, Michel (Leiden University Medical Center) van Lieshout, Lisette (Leiden University Medical Center) Hokke, C.H. (Leiden University Medical Center) Kreidenweiss, Andrea (T€ubingen University Hospital; German Center for Infection Research (DZIF), Tübingen) Diehl, J.C. (TU Delft Design for Sustainability) Adegnika, Ayola Akim (Leiden University Medical Center; Centre de Recherches Medicales des Lambaréné, Lambarene; Universität Tübingen; German Center for Infection Research, Tübingen) Agbana, T.E. (TU Delft Team Michel Verhaegen) Date 2022 Abstract Diagnosis of soil-transmitted helminth (STH) and schistosome infections relies largely on conventional microscopy which has limited sensitivity, requires highly trained personnel and is error-prone. Rapid advances in miniaturization of optical systems, sensors and processors have enhanced research and development of digital and automated microscopes suitable for the detection of these diseases in resource-limited settings. While some studies have reported proof-of-principle results, others have evaluated the performance of working prototypes in field settings. The extensive commercialization of these innovative devices has, however, not yet been achieved. This review provides an overview of recent publications (2010-2022) on innovative field applicable optical devices which can be used for the diagnosis of STH and schistosome infections. Using an adapted technology readiness level (TRL) scale taking into account the WHO target product profile (TPP) for these diseases, the developmental stages of the devices were ranked to determine the readiness for practical applications in field settings. From the reviewed 18 articles, 19 innovative optical devices were identified and ranked. Almost all of the devices (85%) were ranked with a TRL score below 8 indicating that, most of the devices are not ready for commercialization and field use. The potential limitations of these innovative devices were discussed. We believe that the outcome of this review can guide the end-to-end development of automated digital microscopes aligned with the WHO TPP for the diagnosis of STH and schistosome infections in resource-limited settings. Subject HelminthsSoil-transmittedhelminthiasisSchistosomiasisDiagnosisInnovationOptical devicesDigital microscopeArtificial intelligence To reference this document use: http://resolver.tudelft.nl/uuid:743befe0-abd0-45f4-a6f2-dcc019fb730e DOI https://doi.org/10.1017/S0031182022001664 ISSN 1469-8161 Source Parasitology, 150 (2023) (2), 137-149 Part of collection Institutional Repository Document type review Rights © 2022 Brice Meulah, Michel Bengtson, Lisette van Lieshout, C.H. Hokke, Andrea Kreidenweiss, J.C. Diehl, Ayola Akim Adegnika, T.E. Agbana Files PDF a_review_on_innovative_op ... zation.pdf 706.12 KB Close viewer /islandora/object/uuid:743befe0-abd0-45f4-a6f2-dcc019fb730e/datastream/OBJ/view