Magnetic detection of tumors using nanoparticles

Magnetic detection of tumors using nanoparticles

Dos Santos Otero, G.

French, P.J. (mentor)
Schaart, D.R. (mentor)

Mechanical, Maritime and Materials Engineering

Microelectronics

2016-07-08

The aim of this thesis is to explore the technical possibilities to develop a technique to detect tumors based on the magnetic detection of magnetic nanoparticles, targeted at tumor tissues. The report describes the main principles from magnetism, nano-medicine, nanotechnology and magnetic sensors that underlay the proposed technique. The focus and uniqueness of the thesis lays on the behaviour of the MNP’s and how they can be manipulated in order to be measured. The experimental part of the thesis demonstrates the proof of principle of the detection and localisation of the MNP’s in a sample. No real tissues or biological materials are used for the experiment. Cancer is the highest cause of dead nowadays. The survival rates strongly depend on the detection phase at which the cancer is detected. Currently the most accurate medical imaging technique for the localisation of tumors is MRI. MRI equipment is quite expensive and therefore the MRI scans are reserved for specific medical indications. The development of cheaper, non-invasive imaging techniques has gained a lot of attention in the bio-medical sector. Cheaper imaging techniques are not only interesting for the developed countries, but specially for developing countries. I aim that further development of the of a scanning technique based on the proof of principle demonstrated in this report can provide a cheap technique for the detection and localisation of tumors. The technique can be made cheap because its main physical components are magnetic nanoparticles and magnets, both of which can be produced by cheap processes.The measurements done for the experiment have been done with an Ipad, which demonstrates that no high sophisticated measurement tools are required to build the proposed technique.

tumor detection
particle detection
magnetic nanoparticles

http://resolver.tudelft.nl/uuid:75130538-e826-4abe-b18b-0ce837838a9f

2018-07-31

Student theses

master thesis

(c) 2016 Dos Santos Otero, G.