Print Email Facebook Twitter Selective activation of organocatalysts by specific signals Title Selective activation of organocatalysts by specific signals Author Maity, C. (TU Delft ChemE/Advanced Soft Matter) Trausel, F. (TU Delft ChemE/Advanced Soft Matter) Eelkema, R. (TU Delft ChemE/Advanced Soft Matter) Date 2018-06-20 Abstract Reminiscent of signal transduction in biological systems, artificial catalysts whose activity can be controlled by physical or chemical signals would be of high interest in the design of chemical systems that can respond to their environment. Self-immolative chemistry offers a generic method for the development of catalysts that can be activated by different signals. To demonstrate the versatility of that concept, we synthesized organocatalysts that can be activated by three different signals and that can be used to control two different reactions. In this way the organocatalyst proline is designed as a pro-catalyst that is activated either by the chemical signal H2O2, by light or by the enzyme penicillin acylase. The pro-catalysts were used to exert temporal control over the rate of an aldol reaction and a Michael reaction. To reference this document use: http://resolver.tudelft.nl/uuid:89e0b78e-7190-421d-a75a-1a8910aed8fe DOI https://doi.org/10.1039/c8sc02019a ISSN 2041-6520 Source Chemical Science, 9 (27), 5999-6005 Part of collection Institutional Repository Document type journal article Rights © 2018 C. Maity, F. Trausel, R. Eelkema Files PDF c8sc02019a_1.pdf 850.67 KB Close viewer /islandora/object/uuid:89e0b78e-7190-421d-a75a-1a8910aed8fe/datastream/OBJ/view