Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?

Title

Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?

 Author

Wang, Yonghua (South China University of Technology)
Lan, Dongming (South China University of Technology)
Durrani, Rabia (South China University of Technology)
Hollmann, F. (TU Delft BT/Biocatalysis) ORCID 0000-0003-4821-756X

 Date

2017-04-01

 Abstract

Peroxygenases are promising catalysts for preparative oxyfunctionalization chemistry as they combine the versatility of P450 monooxygenases with simplicity of cofactor-independent enzymes. Though many interesting applications have been reported, today ‘we have only scratched the surface’ and significant efforts are necessary to solve issues related to selectivity of the wild type enzymes and low product titers. For this, further elucidation of the vast natural diversity as well as protein and reaction engineering approaches are discussed.


 To reference this document use:

http://resolver.tudelft.nl/uuid:a345fd42-53c1-4ff9-a154-f0d08e8fb868

 DOI

https://doi.org/10.1016/j.cbpa.2016.10.007

 ISSN

1367-5931

 Source

Current Opinion in Chemical Biology, 37, 1-9

 Part of collection

Institutional Repository

 Document type

review

 Rights

© 2017 Yonghua Wang, Dongming Lan, Rabia Durrani, F. Hollmann
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