Print Email Facebook Twitter Value Conflicts in Designing for Safety: Distinguishing Applications of Safe-by-Design and the Inherent Safety Principles Title Value Conflicts in Designing for Safety: Distinguishing Applications of Safe-by-Design and the Inherent Safety Principles Author Bouchaut, B.F.H.J. (TU Delft BT/Biotechnology and Society) Asveld, L. (TU Delft BT/Biotechnology and Society) Hanefeld, U. (TU Delft BT/Biocatalysis) Vlierboom, A.C.E. (TU Delft Electrical Engineering, Mathematics and Computer Science) Faculty Electrical Engineering, Mathematics and Computer Science Date 2021 Abstract Although both the Inherent Safety Principles (ISPs) and the Safe-by-Design (SbD) approach revolve around the central value of safety, they have a slightly different focus in terms of developing add-on features or considering initial design choices. This paper examines the differences between these approaches and analyses which approach is more suitable for a specific type of research—fundamental or applied. By applying the ISPs and SbD to a case study focusing on miniaturized processes using Hydrogen Cyanide, we find that both approaches encounter internal value-conflicts and suffer from external barriers, or lock-ins, which hinder implementation of safety measures. By applying the Technology Readiness Levels (TRLs), we gain insight in the matureness of a technology (thereby distinguishing fundamental and applied research) and the extent of lock-ins being present. We conclude that the ISPs are better able to deal with lock-ins, which are more common in applied research stages, as this approach provides guidelines for add-on safety measures. Fundamental research is not subject to lock-ins yet, and therefore SbD would be a more suitable approach. Lastly, application of either approach should not be associated with a specific field of interest, but instead with associated known or uncertain risks. Subject Safe-by-DesignInherent Safety Principleslock-insValuesBiochemistryBiotechnology To reference this document use: http://resolver.tudelft.nl/uuid:a37b162b-d02b-4b52-9aeb-d3dd02bd6b61 DOI https://doi.org/10.3390/ijerph18041963 ISSN 1660-4601 Source International Journal of Environmental Research and Public Health, 18 (4), 1-13 Part of collection Institutional Repository Document type journal article Rights © 2021 B.F.H.J. Bouchaut, L. Asveld, U. Hanefeld, A.C.E. Vlierboom Files PDF ijerph_18_01963.pdf 6.95 MB Close viewer /islandora/object/uuid:a37b162b-d02b-4b52-9aeb-d3dd02bd6b61/datastream/OBJ/view