Balancing Long-term Plasticity Mechanisms at the Purkinje Cell in the Olivocerebellar System

Balancing Long-term Plasticity Mechanisms at the Purkinje Cell in the Olivocerebellar System

Hoedemakers, Thijs (TU Delft Mechanical, Maritime and Materials Engineering; TU Delft Cognitive Robotics)

Negrello, Mario (mentor)
Peternel, L. (mentor)
Abbink, D.A. (graduation committee)
Jafarian, M. (graduation committee)

Delft University of Technology
Erasmus MC

Mechanical Engineering | BioMechanical Design

2020-10-22

The olivocerebellar system plays a crucial role in control of movements of the human body in terms of coordination, precision and timing. Long-term plasticity is directly linked to motor learning and control. In this research, we developed a phenomenological model of the olivocerebellar system with balancing of long-term potentiation (LTP) and long-term depression (LTD) at the parallel fiber-Purkinje cell (PF-PC) synapse. By ranging the PF input over frequencies, we found that PCs can select frequencies in a highly non-linear manner. There is a sharp contrast in synaptic weight change between neighbouring frequencies, which is caused by the temporal spiking property of the inferior olive (IO) cell. This research found a novel signal processing capability of the PC.

Olivocerebellar System
Long-Term Plasticity
Resonance
Homeostasis
Purkinje Cell
Inferior Olive

http://resolver.tudelft.nl/uuid:d322af30-5078-4544-97ae-2f4b025a5be2

Student theses

master thesis

© 2020 Thijs Hoedemakers