The value of user centred design lies in the increased product acceptance that can be achieved after new product implementation. In designing for healthcare, barriers that impede successful product acceptance can most often be attributed to the gap that exists between medical professionals and product developers. Centralising the intended user of the product during the design phases, and allowing user input and contextual factors to shape the design will help evade these barriers and support product acceptance of any innovation. Innofuse’s innovation comprehends a new principle for merging various drugs and nutrition within an IV set that connects a patient to an IV therapy system. Their innovation was triggered by clinical feedback, describing a lack of system control and research findings illustrating issues with the current performance of the IV sets that are used. Innofuse’s objective is to develop an IV set for simultaneous infusion of drugs and nutrition that supports a more accurate and immediate administration. IV therapy, referring to the infusion of fluids directly into a patients bloodstream, is employed in several area’s of healthcare. The consequences for inaccurate or delayed drug administration, differ between these area’s, and between their respective patient groups. Innofuse focusses on developing an innovative IV set for Neonatal Intensive Care, because the smallest fluctuations in dosages or drug administration delays, have the most severe consequences in pre-term or newborn infants. The need for innovation has been recognised by the departments that provide Neonatal Intensive Care, including physicians and nursing staff. However, resistance towards change, remains a barrier that impedes new product implementation and acceptance in the current care context. This thesis will investigate the barriers for new product acceptance in healthcare, and address contextual factors specifically for the implementation of an new IV set for Neonatal Intensive Care. It will provide recommendations to assist evading barriers or eliminating them, and create guidelines for the product to be designed that suit these recommendations. The approach that was followed entails close collaboration with the context, it stakeholders, and mainly its key user, the nursing staff. A generative session provided insight in current IV therapy practise in the Neonatal Intensive Care Units and actual inconveniences perceived by the staff on a daily basis. Main themes that were uncovered by contextual research include: product-user communication, a sense of feedback regarding product related actions, user confidence to positively influence risk-benefit assessment and inconveniences with fluid flow distinction. Preliminary designs, that challenge these themes, have been created and assessed in an iterative process. During a course of five months several design concepts have been detailed and evaluated. These concepts were underlined with principles of “guiding correct use”, “shape correction”, and “shape completion”. The use of several contextual design models and methods, lead to a final design proposal that was evaluated through user testing in a simulated environment. This final design is called Tulive. User testing showed the need for feedback of human actions on more levels, and the value of simplistic and unambiguous use cues. A proof of the principle of “shape completion” was provided by the results of this test, and complemented by recommendations for further development of Tulive. The user centred, collaborative approach, including several feedback moments with intended users, and the implementation of those findings into new concepts, decreases the gap that exists between healthcare professionals and the product development industry. It has proved promising for other challenges in healthcare design, that strive to achieve product acceptance in their respective contexts