Chitosan cross-linked poly(acrylic acid) hydrogels: drug release control and mechanism

Chitosan cross-linked poly(acrylic acid) hydrogels: drug release control and mechanism

Wang, Y. (TU Delft ChemE/Advanced Soft Matter; East China University of Science and Technology)
Wang, Jie (East China University of Science and Technology)
Yuan, Z. (East China University of Science and Technology)
Han, Haoya (East China University of Science and Technology; Technical University of Berlin)
Li, Tao (East China University of Science and Technology)
Li, Li (East China University of Science and Technology)
Guo, Xuhong (East China University of Science and Technology; Shihezi University)

2017-04-01

Chitosan has been used to cross-link poly(acrylic acid) to give three pH-sensitive hydrogels designed to control the release of the drugs amoxicillin and meloxicam. The extent of cross-linking and solution pH was found to dominate the swelling behavior of these hydrogels as shown by scanning electron microscopy and swelling time dependencies. The rates of release of amoxicillin and meloxicam from the loaded hydrogels increased with increase in pH consistent with the extent of hydrogen bonding between hydrogel components and between the hydrogel and the drugs being important determinants of release rate. Both the Korsemeyer-Peppas and Weibull models fitted release data consistent with drug release occurred through a combination of drug diffusion and hydrogel relaxation processes. These hydrogels appear to provide an ideal basis for controlled drug delivery systems.

Chitosan
Drug delivery
pH sensitive hydrogel
Release mechanism

http://resolver.tudelft.nl/uuid:f7d8f441-53a6-4210-ac3d-0fb6609cb9f5

https://doi.org/10.1016/j.colsurfb.2017.01.008

2019-01-21

0927-7765

Colloids and Surfaces B: Biointerfaces, 152, 252-259

Accepted Author Manuscript

Institutional Repository

journal article

© 2017 Y. Wang, Jie Wang, Z. Yuan, Haoya Han, Tao Li, Li Li, Xuhong Guo